Erythromycin B: conformational analysis and antibacterial activity
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چکیده
منابع مشابه
Antibacterial activity of 2'-esters of erythromycin.
The effect of esterification at the 2'-position of desosamine on the antibacterial activity of erythromycin was investigated by determining the bacteriostatic and bactericidal activities of erythromycin and a number of its 2'-esters on S. aureus and relating these activities to the hydrolysis rates of the esters. These studies, together with comparison of the inhibition of protein synthesis in ...
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Side chain-to-side chain cyclizations represent a strategy to select a family of bioactive conformations by reducing the entropy and enhancing the stabilization of functional ligand-induced receptor conformations. This structural manipulation contributes to increased target specificity, enhanced biological potency, improved pharmacokinetic properties, increased functional potency, and lowered m...
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The proton magnetic resonance spectra of someerythromycin aglycones have been investigated at 100 MHzin both deuteriochloroform and pyridine-d5 solvents. Utilizing information derived from pyridine solvent J-values (J= £CDC13-£C5D5N) and spin-spin coupling constants for vicinal protons, the preferred approximate conformations of these 14-membered lactone ring systems in solution have been shown...
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Nerium indicum [Family:Apocynaceae] is commonly known as Arali [Tam] found throughout India, and has been used in the treatment of cancer, cardiotonic, leprosy and skin diseases. Plant parts such as root, bark and leaves are used. The present study is therefore undertaken to analyse its phyto chemical constituents in solvents like Benene, Chloroform and Alcohol and to screen its antibacterial a...
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ژورنال
عنوان ژورنال: MedChemComm
سال: 2011
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c0md00251h